مرجع دانلود پاورپوینت های درسی

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بسم الله الرحمن الرحیم Bordetella pertussis http://www.hhmi.princeton.edu/sw/2002/psidelsk/Microlinks.htm Bordetella pertussis Basics Aerobic, Gram negative coccobacillus
Alcaligenaceae Family
Specific to Humans
Colonizes the respiratory tract
Whooping Cough (Pertussis) Bordetella pertussis Source: WHO/IVB pneumococcal (28%)
measles (21%) rotavirus (16%) Hib (15%) pertussis (11%) tetanus (8%) 76% 24% yellow fever (1%)
diphtheria (<1%)
polio (< 1%) { Estimated annual childhood deaths, 2002 10.5 million deaths under 5 years of age
1.4 million from diseases where vaccination is currently available
1.1 million from diseases where vaccines will be available by 2008 Meningococcal (< 1%) Reported Pertussis Cases
U.S., 1922-2003* Pertussis in a vaccinated country vs a non vaccinated country Low vaccine coverage
*High morbidity and mortality in infants
*Regular asymptomatic contacts throughout life
*Unknown epidemiology in adults High vaccine coverage
*Low morbidity and mortality in infants
*Few asymptomatic contacts throughout life
*Increase in susceptible adolescents and adults Why speaking about Pertussis? Iran pertussis incidence 2010 : 0.5/ 100000
DTP3 coverage more than 95% روند ميزان بروز سياه سرفه محتمل و پوشش واكسن ثلاث نوبت سوم
(جمهوري اسلامي ايران 1391-1370) فراواني موارد محتمل سياه سرفه برحسب دانشگاه علوم پزشکی 1391 توزیع جغرافیایی موارد مثبت بیماری سیاه سرفه دركشور 1391 Bordetella pertussis virulence determinants TCT The incubation period of pertussis is usually 7 to 10 days, with a range of 4 to 21 days.
The clinical course of illness is divided into three stages.( age, vaccination, waning)
1/ The catarrhal stage is characterized by the onset of runny nose, sneezing, low-grade fever, and a mild cough. Cough gradually becomes more severe (1-2 weeks)
Classic Manifestation 2/ The paroxysmal stage is characterized by coughing fits (paroxysms), which may be followed by a high-pitched inspiratory whoop, vomiting, and/or apnea. (1-6 weeks), but may continue for 10 weeks

Classic Manifestation 3/The convalescent stage is characterized by fewer paroxysmal coughing episodes and usually disappears in 2-3 weeks, but may continue for months Complications Losing weight, pneumonia, otitis, seizure, encephalopathy, apnea
Epistaxia, melena, subdural hematoma, inguinal hernia, rectal prolapse, Infants The severity of pertuss...